That makes Foden almost certain to be recalled when the England manager announces his squad on Thursday lunchtime; Greenwood’s prospects have improved, too.Foden has already made 10 appearances for City this season, and in the last fortnight, he’s scored in both the Premier League (against West Ham) and in the Champions League (against Porto).Meanwhile, injury to Danny Ings frees up a spot among the attackers for Greenwood with Southgate also likely to name an enlarged squad of up to 30 players, as he did last month, to offer more cover.- Advertisement – But Greenwood has not completed a full 90 minutes for United this season, and is yet to score in his five Premier League appearances. He did, though score on his Champions League debut against RB Leipzig.James set for England omission as he serves suspension England will be without Chelsea defender Reece James for their Nations League fixtures against Belgium and Iceland as he serves his two-match suspension for a red card against Denmark last month.Meanwhile, Manchester United captain Harry Maguire is likely to maintain his place in the squad, but will miss the match against Belgium as he was also sent off against Denmark.Maguire will only serve a more lenient one-game ban because he received two yellow cards, while James was given a straight red after using “abusive language to a match official” when he confronted the referee after the final whistle. – Advertisement – Phil Foden is expected to be recalled to the senior England squad by manager Gareth Southgate on Thursday, with Mason Greenwood also under consideration.England begin the November international break with a friendly match against the Republic of Ireland, before taking on Belgium and Iceland in the Nations League.- Advertisement – Southgate feels the pair have been punished sufficiently for breaching coronavirus rules while representing the team in Iceland in September and is ready reintegrate them into the squad. Image:Reece James is suspended for two matches for his red card against Denmark The Manchester City and Manchester United youngsters were sent home from Reykjavik in September after meeting two local women inside the team hotel. They were also left out of last month’s England squad.But Southgate has decided they will now be judged on form alone, rather than their previous indiscretions.- Advertisement – Image:England manager Gareth Southgate could include Foden and Greenwood in the squad
Month: November 2020
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Cell culture is a known technology that is used for vaccines such as inactivated polio vaccine, but in the United States it has never been applied to flu. Moving flu vaccine production from eggs to cell culture would simplify manufacturing in several key areas. It would free manufacturers from the necessity of procuring enough eggs up to a year in advance. By dispensing with eggs, it would eliminate the need for putting a pandemic virus through reverse genetics, shaving 4 to 6 weeks off vaccine production. And because the vaccine virus is grown in giant industrial fermenters, it could offer a vast increase in production capacitybut only if manufacturers or governments make significant capital investments (see Bibliography: GlaxoSmithKline 2005, Novartis 2006) or manufacturers quickly convert the 2.5 million liters of cell-culture capacity (see Bibliography: FDA 2007: Committee meeting transcript) in use around the world for other pharmaceutical products. Either method of creating additional capacity would require the approval of regulatory bodies such as the Food and Drug Administration (FDA) before production could begin, unless governments enacted some form of emergency release. Nov 1, 2007 (CIDRAP News) Frustration with the slow pace of pandemic-vaccine achievement has spurred second looks at both old and new technologies, such as using whole influenza viruses instead of fragments or growing flu viruses in cultures of mammalian cells instead of in eggs. The pandemic vaccine puzzle Pros and cons of live vaccinesLive-attenuated vaccine has been the Cinderella of the seasonal flu vaccine world, struggling for market share since it was introduced in 2003 by MedImmune (now part of AstraZeneca). Even during flu-shot shortages, its acceptability was hampered by restrictive FDA indications limiting its use to 5- to 49-year-olds, as well as a formula that required physicians to keep it frozen (see Bibliography: Rosenwald 2007). The vaccine was relaunched this year with a new formula that requires only refrigeration, along with a broadened indication permitting use in children as young as 2 years old, backed by research showing that it protected young children better than a shot (see Bibliography: Belshe 2007). But additional investment at least is beginning: The Department of Health and Human Services (HHS) awarded $97 million to one manufacturer in 2005 and just over $1 billion to five manufacturers in 2006 (see Bibliography: HHS 2006), and manufacturers Novartis and GlaxoSmithKline have both begun building cell-culture plants in the United States. The first cell-culture vaccine for seasonal flu, made by Novartis, was approved by European Union authorities in June (see Bibliography: Novartis 2007: Novartis gains European approval). Part 1: Flu research: a legacy of neglectPart 2: Vaccine production capacity falls far shortPart 3: H5N1 poses major immunologic challengesPart 4: The promise and problems of adjuvantsPart 5: What role for prepandemic vaccination?Part 6: Looking to novel vaccine technologiesPart 7: Time for a vaccine ‘Manhattan Project’?Bibliography “Although such an event may not be of concern in the face of widespread disease from a pandemic strain of influenza, it would clearly be an unfavorable outcome if the threatened pandemic did not materialize,” Catherine Luke and Kanta Subbarao of the National Institutes of Health (NIH) wrote last year. They called for clinical trials of live-attenuated pandemic vaccine candidates in which, to eliminate the risk of reassortment, participants would be kept in inpatient isolation. “The risk for reassortment must be carefully considered by public health authorities before a decision is made to introduce a live, attenuated vaccine in a threatened pandemic,” they stated (see Bibliography: Luke 2006). Editor’s note: This is the sixth in a seven-part series investigating the prospects for development of vaccines to head off the threat of an influenza pandemic posed by the H5N1 avian influenza virus. The series puts promising advances in vaccine technology in perspective by illuminating the formidable barriers to producing large amounts of an effective and widely usable vaccine in a short time. Part 5 looked at the idea of vaccinating people before a pandemic with a best-guess vaccine and following up later with a vaccine matched to the emergent pandemic strain. Among older and known technologies, the lure of cross-reactive protection has spurred a second look at inactivated whole-virus and live-attenuated flu vaccines. Some whole-virus trials have returned encouraging results. But in the past, whole-virus vaccines’ much higher rate of adverse reactions has kept them out of commercial use in the United States. As a result, “if whole-virus vaccines are confirmed to be more immunogenic than subvirion vaccines, this will pose challenges to manufacturers and regulators, since it will require substantial changes to existing licensed production processes,” Iain Stephenson of University Hospital-Leicester and colleagues observed in Lancet Infectious Diseases (see Bibliography: Stephenson 2006: Development of vaccines against influenza H5). The promise of cell-culture productionThe simplest but in some ways most challenging proposals for addressing the slow development of pandemic vaccines are ones that directly address the shortfall in flu antigen by radically changing production techniques. Such approaches may yield cross-protection against various H5N1 strains, shorten the production timeline, or increase the amount of vaccine that can be produced. As with the inactivated subvirion or split-virus vaccines, however, much of the research into new types of vaccines and forms of delivery is in its early stages, and the vaccines could be years away from marketability. Few of them pass the real-world tests specified recently by David Fedson, MD, in the Permanente Journal. Fedson, a retired vaccine-industry executive who has analyzed pandemic vaccine planning, wrote that the vaccines must be “scientifically promising,” they must be “licensed or near licensure,” and “the global industrial capacity to produce them must be large and already in place” (see Bibliography: Fedson 2007: New approaches). Alternate routesSome researchers have urged attention not to new vaccines, but to new methods of administering vaccines. Intradermal vaccination appears to provoke acceptable levels of immunity while using only 20% to 30% of the standard intramuscular dosebut the injection technique is more challenging and may not be feasible for mass vaccination programs that might use less-trained volunteers (see Bibliography: Haaheim 2007). A refinement of the cell-culture strategy involves isolating the flu virus’s hemagglutinin gene and using recombinant technology to express the hemagglutinin in insect cells grown in bioreactors. The main commercial proponent of this process, Protein Sciences Corp., claims it can halve the standard production timeline while delivering higher yields (see Bibliography: Lauerman 2007). The baculovirus-expressed recombinant product has been successfully tested for safety and immunogenicity (see Bibliography: Treanor, Schiff 2006; Treanor, Schiff 2007), and the company has said it plans to submit a trivalent, seasonal-flu version of the vaccine to the FDA for licensure before the end of 2007 (see Bibliography: Protein Sciences Corp. 2007). Submission of a recombinant pandemic vaccine would follow approval of the seasonal vaccine, chief operating officer Manon Cox said at an FDA hearing earlier this year (see Bibliography: FDA 2007: Committee meeting transcript). In another novel suggestion, academics from the University of Hong Kong recommended recently that health authorities consider giving lower-than-planned doses of vaccine during a pandemic, arguing that vaccinating more people with a reduced dose could create a mass effect large enough to slow down spread of the disease (see Bibliography: Riley 2007). That approach too has drawbacks, Christophe Fraser of Imperial College London said in a commentary: “We must . . . consider whether anyone is ready for the potential consequences of deploying a suboptimal vaccine in an uncertain attempt to maximize our herd protection, with a possible reduction in the extent of protection of individuals” (see Bibliography: Fraser 2007). The Holy GrailThe Holy Grail of flu vaccineand the object so far of the greatest wistfulnessis a universal vaccine. “The optimal long-term solution to pandemic vaccination is the development of a new influenza vaccine against an antigen that is present in all influenza subtypes and does not change,” Ben Schwartz and Bruce Gellin of HHS’s National Vaccine Program Office wrote in 2005 (see Bibliography: Schwartz 2005). So far, however, vaccines based on conserved regions of the virus such as the M2 protein have shown only the ability to reduce disease, not to prevent infection, and have been tested largely in animals, though one clinical trial in humans began last summer (see Bibliography: Acambis PLC 2007). Because they contain live virus, live-attenuated vaccines provoke multiple types of immunity. In studies they have been shown to protect against both the strains from which vaccine candidates were derived and against drifted (slightly mutated) strains as wellcharacteristics that make them highly appealing to pandemic planners (see Bibliography: Belshe 2004). They also grow in eggs at a much higher volume than inactivated vaccines (see Bibliography: Monto 2007). But their live-virus content is responsible for the vaccines’ greatest potential danger: the possibility that they might lead to reassortment between the vaccine virus and circulating flu strains.
In the first three months of 2018, according to the Croatian Employment Service (CES), the most sought after workers in accommodation, food preparation and serving and wholesale and retail trade were a total of 13.836 workers, mostly waiters / waitresses, maids / maids, cleaners, cooks, salesmen, maids, kitchen workers, assistant cooks, assistant waiters / waitresses, receptionists, tourist animators / tourist animators, etc.In the same period in 2018, 4.984 persons from the records of the Institute were employed in the activities of providing accommodation, food preparation and serving and wholesale and retail of food, mainly waiters / waitresses, maids, cooks, cleaners, assistant cooks. / cook, saleswoman, receptionist, kitchen worker, assistant waiters / waitresses but also other professions.”During these months, regular meetings, visits and selections of major hotel and tourism companies will be organized both on the coast and inland to select seasonal workers who are ready for temporary relocation for employment. These are employers from the Adriatic coast, and who most often visited regional – regional offices such as Osijek, Virovitica, Bjelovar, Slavonski Brod, Sisak, Vukovar, Vinkovci, Zagreb, but also other regional offices.. ” point out from the Croatian Employment Service.1.529 persons were employed in other seasonal activities, mostly in administrative and support service activities – 435, arts, entertainment and recreation – 226, processing – 218, transport and storage – 197, transport and storage – 32, construction – 27 Most seasonal workers by counties are employed in: Split – Dalmatia, Dubrovnik – Neretva, Primorje – Gorski Kotar, Istria and Šibenik – Knin counties.Related news:FINALLY FOUND SOLUTION AGAINST LACK OF LABOR IN TOURISMCONSENSUS OF SOCIAL PARTNERS ACHIEVED: NEW COLLECTIVE CATERING AGREEMENT CONCLUDEDTHE LABOR FORCE IN TOURISM IS STILL A BURNING ISSUETRADE UNION OF ISTRIA, KVARNER AND DALMATIA: MANAGEMENT OF HOTEL HOUSES MUST GIVE UP ENORMOUS PROFITS MADE AT THE ACCOUNT OF LOW LABOR COSTS</p><br />
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The Tourist Board of Central Istria (TZSI), in cooperation with the Pazin tourist agency Contineo, will organize weekly free tours of Pazin and its sights during the months of July and August.Tours in Croatian and English will be organized every Tuesday starting at 10:30 am and departing from Contine, Trg Male funtane 7 in Pazin. As part of the tour, a free tasting of Istrian products is planned, and the Museum of the City of Pazin and the Ethnographic Museum of Istria offer participants a “reduced” ticket price of 15 kuna.By the way, at the beginning of the year, a new visual identity and brand of the Central Istria Tourist Board were presented – Central Istria. Original Istria. More attached.Related news: NEW VISUAL IDENTITY OF CENTRAL ISTRIA TOURIST BOARD PRESENTED
According to the Law on Tourist Boards, the Tourist Board of the City of Pula should adopt a program of activities and financial plan for 2019 by the end of the current year, and in order to include the programs of events and other events they decide to accept in the plan, the Pula Tourist Board program for 2019.Music and stage events, sports events, congresses and more will be co-financed. “Programs that are accepted in order to plan the activities of the Tourist Board of the City of Pula in 2019 will be funded exclusively in the accepted form, which will be defined in the contract, and the costs will be paid directly. ”Point out from the Pula Tourist Board.The deadline for submitting bids is 20.09.2018. year until 15 pm, and more details on how to apply and conditions can be found in the attachment:Attachment: TZ PULA / Calls for proposals for 2019.
The Croatian Tourist Board as a national tourist organization, in accordance with the Strategic Marketing Plan of Croatian Tourism for the period 2014-2020, and other strategic documents, with its promotional activities wants to raise awareness of Croatia as an attractive tourist destination throughout the year, and thus increase demand for Croatian tourist products, increase in tourist traffic and general consumption. Accordingly, the CNTB plans to establish cooperation with partners from the tourism industry, and actively promote the Croatian tourist offer in order to attract more guests on the principle of achieving general benefits for all holders of the destination offer, the invitation states. They are possible partners travel organizers (tour operators and carriers) with all forms of organized programs for Croatia (in air, bus and ship transport) that introduce / strengthen their programs or expand the period of operations in the pre-season and post-season with a tendency to further growth in the next 3 years.Cooperation with the selected partner aims to raise awareness of the Croatia brand in the selected strategic market by targeting potential guests through joint campaigns related to the partner program for Croatia, and using promotional channels, tools and experience of partners in the segment of organized tourism programs. The maximum possible share of the CNTB in the joint campaign in the lease can be up to 50% of the costs. As they point out from the CNTB, priority will be given to applications from partners who want to implement and participate in joint campaigns with a minimum of 50.000 Euros net own funds.More about the terms of the call for expressions of interest for the implementation of strategic promotional campaigns in emitting markets in 2019.Attachment: INVITATION to express interest in the implementation of strategic promotional campaigns in emitting markets in 2019 Be sure to pay attention to the call for joint advertising in 2019 published today.RELATED NEWS:PUBLIC INVITATION FOR JOINT ADVERTISING IN PUBLIC AND PRIVATE SECTOR PROMOTIONAL CAMPAIGNS IN 2019.
Airbnb recently released the results of the first quarter of this year, which showed that their marketing costs are rising quite sharply, so this move to work with Google could have important financial implications when Google starts monetizing the feature. Airbnb’s trial debut on Google, in case it becomes the standard way to distribute their offerings, is strategically important to the company because of the planned initial public offering next year. Airbnb doesn’t seem to be afraid to rely on Google to a greater extent than the advertising itself through the platform, as they have done so far. Google’s new service works in such a way that when users search for accommodation, through the Google search interface, they can select an online agency such as Airbnb and make a reservation on the website of the said agency. Airbnb’s participation in this program is a “victory” for Google, which seeks to make its travel platform comprehensive, and without players like Airbnb, there would be a big hole in the supply of offers. But Airbnb’s involvement in this project could only be a small test to see if it’s worth participating. Earlier we wrote that Airbnb refuses to participate in the new program of renting accommodation within Google search, but in recent days their offer of accommodation facilities has started to appear on Google. For now, the offer of holiday homes and apartments appears only in a few European cities such as Paris, Amsterdam and Madrid, reports Shift. Airbnb’s participation in Google’s program, which could be a shorter or longer-term experiment, is significant because until recently, Airbnb was one of the few major players among online travel agencies that was absent from Google’s private rental rental site, which launched this year . Source / photo: Skift; Google Trips
The Call for Proposals for Quality Labels has been published, which awards grants to exercise the right to use quality labels: Croatian quality i Originally Croatian. Znak Croatian quality carry products that are produced or services provided in the territory of the Republic of Croatia, and meet a higher level of quality than that established by the legislative framework and normative criteria for the type and category of product. The mark is recognition of the Croatian manufacturer / service provider and product / service, and at the same time it is a guarantee to the consumer that it is a product / service that satisfies the highest level of quality and represents the top quality in the world offer. The aim of the Call is to increase the visibility of the quality of services and products of SMEs, which will provide the preconditions for increasing revenues from sales, exports and overall competitiveness and consequently contribute to the creation of Croatian identity in the common and world market. The highest amount of support that can be awarded to an individual project is HRK 75.000,00. You can find more details and tender documentation here. Znak Originally Croatian carry high quality products and services of the Republic of Croatia that were created as a result of research and development work, invention, innovation or long tradition. The call is intended for micro, small and medium-sized enterprises with the aim of increasing their competitiveness by obtaining quality labels and contributing to increasing the recognition of Croatian products and services on the open market. Cover photo: Lukas, Pexels.com / Illustration HrTurizam.hr
In the current state of emergency, where practically all economic sectors are directly affected, especially the tourism sector, dialogue and understanding of all, including the social partners, is more important than ever. Due to the pandemic of the COVID-19 virus, employers in the hospitality and tourism industry have been suspended for a long period of time and are unable to comply with the obligations agreed in the branch collective agreement. In order to maintain jobs and ensure the regular continuation of business in the industry after the end of the pandemic, HUP – Association of Hospitality and Tourism, Croatian Trade Union of Tourism and Services te Trade Union of Istria, Kvarner and Dalmatia signed the Agreement repealing the Collective Agreement on Hospitality (signed on December 20, 2019) and its Annex (signed on February 4, 2020) In the hope that part of the tourist season 2020 will still happen, it is important to preserve domicile workers who will then take responsibility for doing work to the satisfaction of guests and employers, who without them can put the key back in the lock of all facilities, said Eduard Andrić, President of the Trade Union of Tourism and Services of Croatia and added: “We expect that in accordance with the agreement at the branch level, employers, primarily those who are members of HUP – Association of Employers in Hospitality, do not cancel domestic collective agreements, but by concluding agreements with their union branches, and their validity until the end of government emergency measures. rights and obligations for the purpose of preserving all jobs as we have done together so far ” The signatories of this branch agreement agree that the provisions of the Collective Agreement on Hospitality, including Annex I, will not apply until the decision of the competent state authorities on the termination of emergency measures caused by the COVID-19 pandemic. Upon the cessation of the emergency measures conditioned by the COVID-19 pandemic, the signatory parties will jointly, by a new Agreement, agree on the termination of the moratorium and the continuation of the provisions of the Collective Agreement on Catering. Due to extraordinary circumstances, it is necessary to adopt extraordinary measures, which must enable us to continue working after the crisis, which will, we hope, end soon. – Marina Cvitić, President of the Trade Union of Istria, Kvarner and Dalmatia. “The social partners in tourism have once again shown the importance of cooperation and agreement between employers and trade unions in all situations, and that they are rightly an example of the social dialogue that should be sought at all levels.” said Natali Komen Bujas, director of HUP’s Association of Hospitality and Tourism, and thanked the unions for their cooperation and trust. “Due to extraordinary circumstances, it is necessary to adopt extraordinary measures, which must enable us to continue working after the crisis, which we hope will end soon. This means that we must all do everything together to save jobs, to ensure the regular payment of workers’ salaries. Now more than ever, social dialogue and understanding of the social partners is important. We must be accountable to both workers and employers and take joint measures so that the consequences of not taking adequate measures do not ultimately deepen the chronic shortage of workers after the coronavirus crisis. ” said Marina Cvitić, President of the Trade Union of Istria, Kvarner and Dalmatia, and concluded that they expect the Government of the Republic of Croatia to urgently adopt further measures with the aim of further relieving this activity, which will be felt long after the end of emergency measures.