The amount of clinical data that drug companies must share with the public could soon vastly expand under a U.S. regulation proposed today. Trial sponsors would need to report summary results for drugs and devices that are never approved—and not just for products that reach the market—under the proposal.The goal of the plan, released by the U.S. Department of Health and Human Services (HHS), is to ensure that summary results for drugs that fail in trials, or are dropped for other reasons, still make it into a public database: ClinicalTrials.gov. Sharing these results should not only be useful for researchers, but also “helps fulfill society’s ethical responsibility” to people who volunteer for trials, said National Institutes of Health (NIH) Director Francis Collins during a press teleconference. “We owe to our patients, to our participants in these trials, the explanation of what happened.” Sharing the data may also help researchers avoid duplicating failed trials, officials say.Launched at Congress’s request in 2000, NIH’s ClinicalTrials.gov now contains registration data for more than 178,000 trials; all sponsors of trials regulated by the U.S. Food and Drug Administration (FDA) are supposed to register. As a result of a 2007 law, within 1 year of the completion of a trial, drug companies must also submit summary results that include information such as the number of participants, their age and gender, outcomes, and adverse events. 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Under the new rule proposed by HHS, companies will also need to report results for unapproved products. That should add another 100 to 150 reports to the 100 summaries the database now receives each week, said Deborah Zarin, director of ClinicalTrials.gov.Trial sponsors can ask for an extension of up to 3 years if they are still seeking approval for a product. And results still won’t be required for early trials, known as phase I, which test a product’s safety.NIH also plans to require that results for all clinical trials that it funds, no matter how early or small, be submitted to ClinicalTrials.gov. At the moment, only investigators conducting trials of products regulated by FDA must register the trial and report results. A draft policy released today will mean that results for another 650 trials per year will be added, NIH officials say.Both the NIH and HHS draft rules also clarify such details as who should submit data and when it must come in; trials must be registered within 21 days of enrolling the first patient, for example. This will make it easier to enforce compliance with the rules, for example by withholding funding for NIH grantees or imposing fines on companies regulated by FDA, said Kathy Hudson, NIH’s deputy director for science, outreach, and policy. The public may eventually be able to check the database to see if researchers have met the deadlines, providing a “wall of shame,” NIH officials joked.One advocate of clinical data sharing, Peter Doshi of the University of Maryland School of Pharmacy in Baltimore, says he welcomes the new requirements. Some NIH-funded trials “are not published for years and years,” he notes. And often negative results never appear in a journal. “That’s not good from an evidence perspective and it’s embarrassing from a policy perspective. There’s an interest in trying to close these gaps.”Requiring that trial results for unapproved drugs be shared is also a positive step, Doshi says. “You’re reducing the chance that somebody will redo experiments that were already done and put people in harm’s way because the research wasn’t shared,” he says.However, the summary results in ClinicalTrials.gov can be confusing—they sometimes conflict with results reported in journals—and they lack details that could help researchers understand the data, Doshi notes. By contrast, the European Medicines Agency plans to make detailed clinical data reports publicly available and to provide data on individual patients to researchers—albeit only for approved drugs.“The white elephant in the room is that FDA sits on more data, across more drugs, across more therapeutic indications than anybody else on the planet,” Doshi says. “And their attitude is, ‘Great idea [to make the data public], let somebody else take care of this.’ ” Doshi is an associate editor of The BMJ, which is part of a group called AllTrials that is pushing for release of detailed clinical trial data.NIH’s Hudson said the agency is looking at whether to require access to data on individual patients without compromising privacy. The proposal also asks for input on whether trial sponsors should be required to submit their protocol to help the public understand the results.NIH and HHS are taking public comment on the two proposed policies until 19 February.*Correction, 20 November, 7:56 a.m.: The number of additional weekly submissions the new rule is expected to generate has been corrected. The correct numbers are 100 to 150 addtional submissions, not 200 to 250.
Police teams find crossbows, bows in HK university PLAY LIST 01:29Police teams find crossbows, bows in HK university01:35Panelo suggests discounted SEA Games tickets for students02:49Robredo: True leaders perform well despite having ‘uninspiring’ boss02:42PH underwater hockey team aims to make waves in SEA Games01:44Philippines marks anniversary of massacre with calls for justice01:19Fire erupts in Barangay Tatalon in Quezon City Read Next Families in US enclave in north Mexico hold sad Thanksgiving LATEST STORIES The Warriors improved to 3-0 since the All-Star break and beat the Knicks for the eighth straight time, one shy of their longest winning streak in the series. They won nine straight in 1963-64.A night shy of the five-year anniversary of Curry’s 54-point Madison Square Garden masterpiece, the Warriors showed how many weapons they have around him now, making 15 3-pointers and putting six players in double figures.The third quarter has been when the Warriors separate themselves from opponents, and this was the fifth time they outscored a team by 20 or more in the period.“I still don’t have an answer as to why the third quarter is what it is, like anything specific, beyond just the fact that we can wear teams down over the course of 48 minutes,” Curry said. And it might take 24, 26 minutes to really create that separation and gain that momentum, and we come out of the halftime with some juice, some energy and it’s winning time. So that’s my best explanation for it and hopefully it continues.”This onslaught started innocently enough, with Green banking in a 3-pointer. Curry and Thompson followed with much prettier ones, and when JaVale McGee followed with a basket it was an 11-0 start to the second half and a double-digit lead in about 2 ½ minutes.ADVERTISEMENT New York Knicks guard Courtney Lee, right, defends against Golden State Warriors guard Klay Thompson (11) during the first half of an NBA basketball game, Monday, Feb. 26, 2018 in New York. Knicks forward Michael Beasley (8) watches the action. (AP Photo/Kathy Willens)NEW YORK — Draymond Green threw his arms up in triumph, celebrating his go-ahead 3-pointer.Never mind that it banked in, a rather ugly look on a team that shoots it beautifully.ADVERTISEMENT AFP official booed out of forum Davis explodes for 53 as Pelicans trump Suns for 6th straight win John Lloyd Cruz a dashing guest at Vhong Navarro’s wedding “It sparked the run, didn’t it?” Green said. “It got everybody going by an amazing shooter.”And the Warriors didn’t slow down the rest of another awesome third quarter.FEATURED STORIESSPORTSWATCH: Drones light up sky in final leg of SEA Games torch runSPORTSLillard, Anthony lead Blazers over ThunderSPORTSMalditas save PH from shutoutKlay Thompson scored 26 points and Stephen Curry had 14 of his 21 in the period, when Golden State ran another opponent off the floor on its way to a 125-111 victory over the New York Knicks on Monday night.Kevin Durant added 22 points and nine rebounds for Golden State, which trailed by one at halftime before outscoring New York 39-18 in the third to end things early. The highlight show continued from there, with center Zaza Pachulia dribbling behind his back to lead a fast break and Curry converting a four-point play for a 20-point bulge later in the period.“It’s tough. Those guys were so big and athletic, anyone in their team could switch,” the Knicks’ Tim Hardaway Jr. said. “So it was tough to get around them.”Emmanuel Mudiay scored 20 points and Trey Burke had 18 for the Knicks.Mudiay had 13 points in the first seven minutes and 14 in the first quarter to lead all scorers and give the Knicks a 39-37 edge.TIP-INSWarriors: Rookie Jordan Bell returned after missing 14 games with inflammation in his left ankle. He had three points. … Green’s technical assessed with 1:04 left in the first half of Saturday’s rout against Oklahoma City was rescinded by the NBA on Monday, putting him back at 14 for the season and two away from an automatic suspension.Knicks: F Michael Beasley received five stitches for a cut on his right eyebrow after he was hit in the second quarter but returned to play in the third. … New York is off until Friday, when it visits the Los Angeles Clippers to open a four-game road trip.MAGIC MSG MOMENTCurry’s 54-point game is still his career high, as he went 11 for 13 from 3-point range. The Knicks ended up winning it though, as Raymond Felton blocked his jumper to lead to J.R. Smith’s tiebreaking basket with 1:10 left in a 109-105 victory. That remains New York’s last home win over Golden State.CAN’T BE BADKnicks coach Jeff Hornacek, on the challenge of defending the Warriors:“Can’t have any ‘my bads,’” he said. “‘My bads’ turn into 3-point shots that they knock in.”UP NEXT LOOK: Iya Villania meets ‘Jumanji: The Next Level’ cast in Mexico Typhoon Kammuri accelerates, gains strength en route to PH MOST READ Brace for potentially devastating typhoon approaching PH – NDRRMC Warriors: Visit Washington on Wednesday.Knicks: Visit the Los Angeles Clippers on Friday. Google honors food scientist, banana ketchup inventor and war hero Maria Orosa Pussycat Dolls set for reunion tour after 10-year hiatus Don’t miss out on the latest news and information. View comments
medalSimone Bilesworld championshipWorld gymnastics Championship First Published: October 12, 2019, 9:36 PM IST Stuttgart: US gymnastics queen Simone Biles equalled the all-time record of 23 medals at world championships with the 17th world title of her career in the vault final on Saturday.The 22-year-old needs only one more medal from her remaining three finals in Stuttgart to overtake Belarusian male gymnast Vitaly Scherbo, with the uneven bars to come later on Saturday. Biles took her third gold of the week with a winning score of 15.399 points ahead of US team-mate Jade Carey, who finished with silver, while Britain’s Ellie Downie took bronze.The four-time Olympic champion had already won all-around gold and the team event this week to extend her record of most world gold medals.Biles retained the vault title she won in Doha last year by excelling on her two attempts, completing two and a half twists on her second effort.Less than a year before the Tokyo Olympics, Biles can potentially win six medals in Stuttgart with the women’s beam and floor finals to come on Sunday. Get the best of News18 delivered to your inbox – subscribe to News18 Daybreak. Follow News18.com on Twitter, Instagram, Facebook, Telegram, TikTok and on YouTube, and stay in the know with what’s happening in the world around you – in real time.
Home grown company Xolo has launched a new budget phone, the Era 4G in the Indian market at a price of Rs 4,777. The Xolo Era 4G is successor to the company’s Era phone and supports “4G VoLTE ensuring superior quality audio/video calls and faster call connects.” The phone is now available for registration and will officially go on sale from February 24 exclusively from online retail website Snapdeal.Xolo’s Era 4G comes with a 5-inch HD display and is powered by a 1.5 GHz quad-core processor (unspecified chipset) coupled with 1GB of RAM and 8GB of internal memory which is further expandable by up to 32GB via microSD card slot. The phone sports a 5-megapixel camera on the rear camera along with a 2-megapixel camera on the front.The Era 4G comes with multilingual support for regional languages such as Assamese, Bengali, Gujarati, Kannada, Malayalam, Marathi, Odia, Punjabi, Tamil and Telugu.The dualSIM phone runs Android 5.1 Lollipop out-of-the-box and will be upgradable to Android 6.0 Marshmallow in the future. It is backed by a 2,500mAh battery.Xolo recently launched its camera-centric budget phone, the One HD in the Indian market at a price of Rs 4,777. The Xolo One HD is an Amazon exclusive. The Xolo One HD comes with a 5-inch HD IPS display and is powered by a 1.3GHz quad-core processor with 1GB of RAM and 8GB of internal storage. It is further expandable by up to 32GB via microSD card. The dualSIM phone runs Android 5.1 Lollipop and supports 3G connectivity. It comes with an 8-megapixel camera on the rear and a 5-megapixel camera on the front. It is backed by a 2,300 mAh battery which is removable.advertisement
Anil Kumble’s fans on Wednesday slammed the Board of Control for Cricket in India (BCCI) after the board’s indifferent birthday wish to the legendary cricketer.The former India captain and one of the greatest bowlers to have played cricket, turns 47 today. The fiery leg-spinner captained India in 14 Tests and oversaw three victories, five defeats and six draws.BCCI in their tweet wrote, “Here’s wishing former #TeamIndia bowler @anilkumble1074 a very happy birthday.”However, the board later deleted its tweet after fans slammed the BCCI for giving Kumble due respect.BCCI @BCCI deletes tweet on Anil Kumble @anilkumble1074 after attack. Damage control mode now #cricket pic.twitter.com/QMurVOfZF2- APRAMEYA .C (@APRAMEYAC) October 17, 2017″Here’s wishing a very happy birthday to former #TeamIndia Captain Mr. Anil Kumble #Legend #HappyBirthdayJumbo,” BCCI later tweeted.Here’s wishing a very happy birthday to former #TeamIndia Captain Mr. Anil Kumble #Legend #HappyBirthdayJumbo pic.twitter.com/uX52m8yYif- BCCI (@BCCI) October 17, 2017Kumble is India’s highest wicket taker in both Tests and one-day internationals. The leg-spinner took 619 wickets from 132 matches in the longest format and 337 wickets from 271 ODIs.Kumble made his Test debut in August 1990 against England at Manchester when he was 19. He made his ODI debut in April earlier that year against Sri Lanka in Sharjah. Kumble’s cricket career was spread over 18 years in which he single-handedly led India to famous victories.The inspirational leader was also appointed the coach of the Indian cricket team in 2016 and during his one-year term, Virat Kohli-led India won five consecutive Test series from June 2016-March 2017. Under Kumble’s guidance, India also registered ODI series win against New Zealand and England, and reached the ICC Champions Trophy final.advertisementHowever, two days after the Champions Trophy Kumble resigned from his post as his partnership with captain Kohli became ‘untenable’.
Jemimah Rodrigues, who scored a match-winning knock for Supernovas against Velocity in the ongoing Women’s T20 Challenge, has revealed that playing the on-drive shot boosts her confidence the most.Sent into bat in their must-win match, the Supernovas scored 142 for 3, thanks to Rodrigues’ 77 not out and then restricted Velocity to 130 for 3 to win the final round-robin league match at the Sawai Mansingh Stadium on Thursday.The 48-ball knock from the 18-year-old was studded with 10 stylish boundaries and a six.Speaking after the match, Rodrigues said: “I think the confidence I get while playing the on-drive is something no other shot gives me. I just tried to get good impact on the ball.”Jemimah Rodrigues is the Player of the Match for her match winning knock of 77* off 48 deliveries.#WIPL pic.twitter.com/WQ4GyRb4ZOIndianPremierLeague (@IPL) May 9, 2019She further revealed that her coach told her to stay at the wicket and not try to hit the ball hard.”I think it was important for me to play throughout. My coach told me to just time the ball and not try to hit it hard. I am batting pretty well. I look forward to the finals and would want to keep things simple,” she added.The two sides will again face each other in the finals on Saturday as the third team, Trailblazers, who also secured the same two points as Velocity and Supernovas, finished last on the basis of net run rate.Also Read | Veda Krishnamurthy defends defensive approach as Velocity qualify for final on NRRAlso Read | Velocity lose to Supernovas but both teams enter finaladvertisement
Transfers Celtic star Tierney prepared to keep Man Utd and Arsenal waiting Chris Burton Last updated 2 years ago 04:04 11/3/17 FacebookTwitterRedditcopy Comments(0) Getty Images Transfers Manchester United Arsenal Celtic Premiership Premier League The highly-rated full-back has been linked with a big-money move to England, but he is in no rush after committing to a new six-year contract Kieran Tierney is prepared to keep the likes of Manchester United and Arsenal waiting on his signature after penning a six-year deal at Celtic.The 20-year-old full-back is among the most highly-rated talents in British football, having starred for the reigning Scottish champions after emerging from their academy system.Bhoys 11/2 to beat St Johnstone 3-0 Article continues below Editors’ Picks Lyon treble & England heartbreak: The full story behind Lucy Bronze’s dramatic 2019 Liverpool v Man City is now the league’s biggest rivalry and the bitterness is growing Megan Rapinoe: Born & brilliant in the U.S.A. A Liverpool legend in the making: Behind Virgil van Dijk’s remarkable rise to world’s best player His efforts have sparked talk of a big-money move to England, with Old Trafford and Emirates Stadium mooted as possible landing spots.Tierney, though, is paying little attention to the transfer talk and is happy to remain at Parkhead for some time yet after committing his long-term future to Celtic.He told the club’s official website in the wake of another eye-catching performance against Bayern Munich in the Champions League: “People are giving me compliments but I don’t like talking about my game too much.“I just work hard every single day in training and see where it takes me, and if I can help the team then that is what I will do.“My aspiration is to work hard every day, train hard and play on the Saturday and hopefully play well and see where it takes me.”The club thought I was doing well enough so they have rewarded me with a new contract, and I’m delighted.“I still had four years so there wouldn’t be much point if they weren’t going to extend my years. It’s great for both parties and everyone is delighted, and it got done so quickly, which is always great.”While believing that he is in the right place at present for his ongoing development, Tierney also feels that he has the perfect manager in Brendan Rodgers.He added: “I know I am still young and I have a long way to go and a lot of learning to do and I’m under the right manager to do that, and that’s why I am so happy.“I have always had aspirations to play for Celtic and that’s what I am doing. I’m very happy here and that’s why I’ve signed a long-term deal.”
The cleanup of spilled oil at Barney’s River in Pictou County is about 90 per cent complete. Containment booms, vacuum trucks, and soil removal efforts have been effective in removing waste oil that spilled from a truck accident on Highway 104 on Aug. 18. Department of Environment officials are at the site daily, monitoring the clean up, which is the responsibility of the trucking company. A preliminary test by Environment Canada of water beneath the surface, downstream from the clean up site, shows no oil was detected. More detailed testing is being done on that sample, and others taken in different parts of the river, on different days. “While the potential risk to human health is minimal, we understand that residents and visitors may have concerns about water quality in Barney’s River,” said Dr. Maureen Baikie, deputy chief medical officer of health with the Department of Health Promotion and Protection. “Swimming should be avoided if you see a sheen on the water, or detect an oil odour.” Officials also advise that the public stay away from the clean-up area, about a five kilometre stretch along the river, or near the containment booms. There are no drinking water wells within 4.5 kilometres of the spill site. A test of water in the nearest well detected no oil in the drinking water. Drinking untreated river water is never recommended as it may contain unhealthy levels of naturally occurring bacteria. The Department of Fisheries and Aquaculture is working with the federal department of Fisheries and Oceans to ensure the long-term health of the fisheries resource and the interests of the anglers are addressed. Anglers should report anything unusual to local Fisheries Officers. “We’ve considered all the factors and see no issue with consuming fish from this river,” said Mike Horwich, director of food protection and enforcement, with the Department of Agriculture. The government will also deliver information to residents in the area next week. Environmental consultants have been employed by the trucking company to begin a monitoring program that assesses potential future impacts to the river. The toll-free number to report concerns about the effects of environmental emergencies in Nova Scotia is 1-800-565-1633.
Chris Stewart APTN National NewsMedia of all forms were in Edmonton over the weekend as the Canadian Association of Journalists held its annual conference and awards gala.APTN was nominated for four national awards, capturing two. APTN Investigates won with Dennis Ward and Murray Oliver taking home the award for human rights reporting for their story, a Soldier Scorned, that detailed an Inuk woman who faced racism and sexual harassment in the military.“You know, Murray and I are the two that are holding on these plaques and stuff (but) a lot of people at APTN work on these stories,” said Ward. “This is a real team effort. That’s how APTN is. A big team.”APTN Investigates took its second award with Melissa Ridgen’s story, Hunting for Work, about Indigenous workers in Winnipeg working under unsafe conditions and getting hurt picking up the city’s garbage.“It’s a great night for APTN,” said Ridgen. “This shows that APTN is covering a lot of stories that matter to Indigenous people.”APTN reporters also took part in journalism panels throughout the weekend.Tina House moderated a panel on missing and murdered Indigenous women where panelists thanked APTN for how reporters have worked on countless stories for many years.Jorge Barrera and Ridgen also hosted a popular panel on how to follow the money on First Nations. The CAJ conference is being held in Toronto next year.
Rabat – After the 1.6 percent registered in 2016, growth forecasts for 2017 have even been revised upwards by the High Commission for Planning (HCP), estimated to reach 4 percent instead of the initial 3.5 announced in January due to significant increases in agricultural activities. During a conference held Wednesday in Casablanca, Ahmed Lahlimi, head of the HCP, announced that the growth rate recorded by his institution is now aligned with that of the World Bank, which had also forecasted 4 percent in a report published in January. These two predictions, however, are less optimistic than that of the government, who in the 2017 FInance Bill projected growth perspectives of 4.5 percent. According to the HCP, the renewed energy of the Moroccan economy is due in large part to the good performance of the world economy but also to certain components of the national GDP. “In an international context that invites optimism, our national economy should improve its performance, but continue to suffer the effects of its structural deficits,” stressed Lahlimi, who also expects the 4 percent growth rate to be maintained in 2018.On the national level, this upward revision can be explained by the “good results of the 2016-2017 crop year,” according to Lahlimi. Rainfall and improvements in area under cultivation are expected to lead to a 200 percent increase in cereal production compared to the 2016 crop year. The agricultural sector is anticipated to help bring the value added of the primary sector to 13.9 percent in 2017 compared to 11.3 in 2016, as well as contribute to GDP growth by to 1.7 percent, instead of -1.4 percent a year earlier. Lahlimi also brought up the performance of non-agricultural activities, which he called a “real Achilles heel of the national economy.” The latter are expected to follow slow growth with 2.5 percent, after 2.2 percent in 2016, far from the average rate of 4 percent experienced during the period 2008-2011. Their contribution to overall economic growth is thus forecasted to be 1.9 percentage points in 2017, instead of an annual average of 2.8 percentage points over the last 10 years, according to the HCP.Moroccan economy dependent on volatile factorsWhile agricultural activities are the main booster of national economic growth, it remains too dependent on volatile natural factors. This instability still persists despite Morocco’s efforts in recent years to reduce dependence on rainfall, notably through the launch of several sectoral strategies and economic reforms. “The low level of diversification and competitiveness of the national supply is at the heart of the fragilities of the demand which would continue to be the engine of national economic growth,” the High Commissioner said. According to Lahlami, this dependence not only drags down the Moroccan economy, but if no efficient reforms are urgently adopted, this disadvantage would continue to increase unemployment, reduce income opportunities, expand social deficits, and increase the dependence on domestic demand for imports. Lahlimi once again stressed the urgent need to accelerate the pace of structural reforms of the Moroccan economy. “Reforms should aim to eliminate all latent threats, both in our economic fabric and our public finances, in the system of development of our human resources and in our way of national and regional governance.”
Starting Tuesday, the west leg of the Sherman Access will be closed for long-term construction.The City of Hamilton says the closure will begin at the bottom of the Sherman Cut and run to Charlton Ave. East.Crews are reconstructing the retaining structure along the roadway and anticipate the closure will last until late November.Downbound traffic coming off the Claremont Access will still be able to access the bottom of the west leg of the Sherman Access to Charlton Ave. East throughout the construction period.The entire length of the Wentworth Stairs will also be closed as crews work to rehabilitate the footings at the base of the stairs and complete proactive work to alleviate erosion along the footpath beside the stairs.The east leg of the Sherman Access will remain open.A section of Dartnall Road on Hamilton Mountain will also be closed for approximately four months beginning Tuesday.The City of Hamilton says Dartnall Road between Rymal Road and Stone Church Road East will be closed for construction that includes road widening, drainage and lighting improvements. There will be access to local businesses on the road during the construction.
According to a news release issued in Geneva, Bertrand Ramcharan “deeply regrets the execution of individuals in Uzbekistan, for whom stays of execution had been requested by the United Nations Human Rights Committee.”In a letter to the Uzbek Government yesterday, Mr. Ramcharan “stressed that these executions render futile review by the Human Rights Committee of these cases, which amount to a grave breach of Uzbekistan’s obligations under the International Covenant on Civil and Political Rights and its Optional Protocol,” the release added.Uzbekistan acceded to the Covenant in 1995. The UN Human Rights Committee is an 18-member panel of independent experts.Mr. Ramcharan, who is Acting High Commissioner during the temporary absence of Sergio Vieira de Mello in Iraq, where his is Secretary-General Kofi Annan’s Special Representative, urged the Government to make all necessary efforts to ensure strict observance of its international human rights obligations and to ensure full cooperation with the Human Rights Committee in the examination of individual cases.
NEW YORK, N.Y. – NEW YORK â€” Standard & Poor’s downgrades its rating on Spain’s debt by two notches, leaving it on the cusp of junk status. A grinding recession, high unemployment and social unrest are limiting the government’s options for stemming the country’s financial crisis, S&P says.The credit-rating agency now rates debt issued by Spain BBB-, its lowest investment-grade status. It had been BBB+.Also on Wednesday, S&P also assigned a negative outlook to the rating, saying it could be further downgraded if Spain’s economic conditions erode further.“Overall, against the backdrop of a deepening economic recession, we believe that the government’s resolve will be repeatedly tested by domestic constituencies that are being adversely affected by its policies,” S&P said.It also cited difficulty in predicting the extent to which other countries in the 17-nation eurozone would come to Spain’s aid. It had previously assumed a key European bailout fund would help recapitalize the country’s shaky banks without piling more debt on the central government in Madrid. But now any recapitalization plan will likely add more debt, S&P said.Investors are worried that Spanish banks could collapse under the weight of an imploding real-estate market.Tensions between Spain’s indebted regional governments and the central government were also cited by S&P for its downgrade.S&P estimates Spain’s economy will contract by 1.8 per cent in 2012 and another 1.4 per cent in 2013. Spanish unemployment is near 25 per cent.Last month, the European Central Bank agreed to buy unlimited amounts of debt by struggling European countries like Spain to help lower their borrowing costs. But the governments first need to apply for bailout.Spain has not applied for a bailout yet. Instead, the government has introduced a series of austerity and labour measures in a bid to bring down its deficit and convince investors it can manage its finances without outside help.The interest rate, or yield, on 10-year Spanish bonds was 5.78 per cent on Wednesday, near a six-month low. That was down from a July 24 peak of 7.54 per cent, near the level that forced Greece, Portugal and Ireland to seek international bailouts. AddThis Sharing ButtonsShare to TwitterTwitterShare to FacebookFacebookShare to RedditRedditShare to 電子郵件Email by News Staff Posted Oct 11, 2012 1:26 am MDT S&P downgrades Spain’s credit rating 2 notches to lowest investment-grade level
I’m far from New York, but I’m happy to know that young people came to the UN once again to express their commitment in the fight against climate change. I encourage them to keep pushing for stronger #ClimateAction. https://t.co/6TuzXLHQiA— António Guterres (@antonioguterres) August 30, 2019 The 16-year-old and two other teens got a preview of the UN General Assembly Hall, where all 193 of the entity’s Member States gather every year to discuss a wide array of international issues, and where Ms. Thunberg is scheduled to speak during the Secretary-General’s Climate Action Summit next month. The Swedish youth activist was greeted by General Assembly President, María Fernanda Espinosa, who tweeted: Welcome, Greta Thunberg and climate activists to the UN in New York. Your determination for climate action has shaken the world and we join you in holding leaders accountable. “Science, not Silence” #ClimateActionNow.She also received praise from UN Secretary-General António Guterres in a Twitter message: “I’m far from New York, but I’m happy to know that young people came to the UN once again to express their commitment in the fight against climate change. I encourage them to keep pushing for stronger #ClimateAction.”Ms. Thunberg, who sailed from Europe to curb carbon emissions from air travel, will attend UN climate summits in New York in September, and in Santiago, Chile, in December. Her 60-foot Malizia II racing yacht, equiped with solar panels and underwater turbines for electric power, docked in New York City on Wednesday, where she was welcomed by a flotilla of 17 sailboats, each representing one of the UN’s Sustainable Development Goals (SDGs).The young environmental advocate has gained media attention since waging a “school strike” for climate action last August.At just 15, she stood alone outside of Swedish Parliament in demostration, calling for drastic change. Since, other impassioned youth have followed her lead and skipped school for the cause.”I would love not to have to do this and just go to school,” Ms. Thunberg told journalists upon arriving onto dry land, “but…I want to make a difference.”
This is the sort of tenacity that ought to be celebrated. A driver in Xi’an China was spotted behind the wheel with a an IV sticking into his arm. Said the Zhou Tao, the driver who snapped the photo, “I couldn’t believe it when I saw the IV pole sticking out of the window and the driver receiving treatment…He obviously didn’t have enough space in the front for the IV pole so he had put it in the back, behind him, sticking out of the window.”Fellow drivers honked at the driver, now being referred to as “Injection Brother,” as they passed him on the highway. Says Tao, “Other motorists couldn’t believe it either, they were sounding their horns at him. Perhaps they were worried he might fall asleep!”AdChoices广告
00:00 00:00 spaceplay / pause qunload | stop ffullscreenshift + ←→slower / faster ↑↓volume mmute ←→seek . seek to previous 12… 6 seek to 10%, 20% … 60% XColor SettingsAaAaAaAaTextBackgroundOpacity SettingsTextOpaqueSemi-TransparentBackgroundSemi-TransparentOpaqueTransparentFont SettingsSize||TypeSerif MonospaceSerifSans Serif MonospaceSans SerifCasualCursiveSmallCapsResetSave SettingsStand Down is underway. The three-day event on the grounds of San Diego High School provides much needed comfort, and importantly, services and counseling for veterans who are homeless.Going into its 40th decade, originally called Operation Stand Down, Stand Down has set the standard for other cities to replicate when it comes to aiding homeless veterans:A roof, food, health care, clothes, a court to resolve misdemeanor offenses that could be thwarting a vet’s moving forward, and speaking of, substance abuse counseling and job counseling.But the event put on by Veterans Village of San Diego, starts with a simple greeting, “we’re glad you’re here.”KUSI was live with Bill Glover, the longtime volunteer who started the welcoming handshake. He told us he wants the people streaming in to know they’re valued as a human being.And every year, we try to focus on a success story.For 17-straight years, Michael Conley arrived here and then went right back to the streets because of addiction issues.Finally, last year, he got into the Veterans Village program at its campus on Pacific Highway,He’s now sober, employed, and has an apartment.I asked him if life was good. “Life is great,” he replied. June 29, 2018 Ed Lenderman, Posted: June 29, 2018 Ed Lenderman Over 800 homeless veterans expected to attend 31st annual Stand Down event Categories: Local San Diego News FacebookTwitter
A 21-year-old was cited for following too close after his pickup slammed into the back of another car Friday morning on state Highway 500, the Washington State Patrol said.According to a WSP bulletin, Sally J. Davidson, 59, of Vancouver was driving her 2007 Subaru Forester east on Highway 500 just before noon Friday. She slowed for traffic near the ramp to southbound Interstate 205 and was rear-ended by a 1983 Chevrolet pickup driven by Jeremy W. Veselka, 21, of Washougal, WSP said.Davidson was sent to PeaceHealth Southwest Medical Center. Her car was totaled.Veselka was uninjured, according to WSP. His car had no reported damage.The crash was caused by driver inattention, WSP said.
He says the cost cutting measures are ill-advised, because the research done there is valuable. Floyd says the ionosphere has a strong impact on satellite communications, but not enough is known about how that works. Floyd says the research conducted in Gakona has far reaching implications for both military and commercial communications systems.“HAARP is in Alaska because we wanted to be underneath a region of concentrated ionosphere called the auroral oval. And we all have marvelled at the Northern Lights, and what that is doing is painting out this hollow ring of concentrated ionosphere, that’s caused by the Earth’s magnetic field. And we wanted to be underneath that auroral oval a good percentage of the time. “He says there’s no better site than Gakona for the research facility. Bob McCoy agrees. McCoy and his fellow researchers argue there’s a lot more science to be done in Gakona. McCoy says there’s a possibility that the defense department could find an entity willing to share the costs of HAARP’s upkeep. The Air Force is paying for HAARP ionospheric research now going on through this month and in May of this year. During that time, HAARP will be inventoried to determine if some of its equipment can be used to support other scientific activities elsewhere. Meredith Mingledorff, a public information officer with the Air Force Research Laboratory at Kirkland AFB in New Mexico, says in an email,“The Air Force favors the transition of the HAARP facility to a basic research organization.”But that depends on funding. If no other organization can be found to pay expenses, “The Air Force plans to decommission the research site…and initiate divestiture in June 2014.” The cost of the deconstruction has not been established yet. “So we’ re transmitting out with a focused beam, doing a very, very, very minute but detectable stimulation of the plasma of the ionosphere with these what are really very standard short wave radio transmissions, but it is just enough to do a cause and effect study of the ionosphere.” It’s been both praised and maligned. Praised by scientists as a tool to gain knowledge about Earth’s ionosphere; maligned as a secret means to develop an ultimate weapon. The HAARP resembles a giant radio antennae. It’s 180 towers are 78 feet tall and have been beaming radio waves into the atmosphere since 1997. The facility covers about thirty acres of Department of Defense land just off the Tok Cutoff, not far from Gakona Junction. The news of its imminent shut-down has alarmed the scientific community. Bob McCoy directs the University of Alaska Fairbanks Geophysical Institute.Download Audio“We’re up here in the subarctic, and we can see how the sun connects to the Earth along the magnetic lines at high latitudes. It would be a shame if this facility went away. “McCoy says there are only three facilites like it in the world.“One in Norway and one in Russia. But HAARP is much more flexible. It’s got a wider frequency range, it can go something like less than three up to ten megahertz, and has quite a bit more power.”HAARP and UAF research projects have been linked for years. And major universities throughout the US remotely access the HAARP facility and it’s information – Cornell and Rice among them. That’s why recent news that the Department of Defense plans to abandon HAARP galvanized McCoy and fellow scientists to make their case to save HAARP to the secretary of defense earlier this year.“So a lot of us realize how important it is, how powerful, how significant the facility is. So we’re trying to figure out ways to keep it alive as an active scientific tool. Last March the National Academy did a workshop and invited in forty- something scientists to testify about the value of the science that has been done and could be done in the future from HAARP.” It is a question of money. In these federal budget – cutting times, the roughly four million dollars a year needed to maintain the facility is getting scrutinized.HAARP is owned by the Air Force Research Laboratory, but was until recently operated by an Anchorage contractor, Marsh Creek.Steve Floyd is the principal systems engineer for Marsh Creek. He says HAARP’s money woes started with last year’s sequestration cuts.“Our contract through Marsh Creek to run the facility, came to an end in the middle of June of 2013. And I guess it’s the sequestration cuts that really squeezed the budget and the Air Force Research Lab decided to save some money and take it dark for a while. “
The makers of Citra, an emulator for the Nintendo 3DS, have released a new emulator called yuzu. This emulator is made for the Nintendo Switch, which is the 7th major video game console from Nintendo. The journey so far for yuzu Yuzu was initiated as an experimental setup by Citra’s lead developer bunnei after he saw that there were signs of the Switch’s operating system being based on the 3DS’s operating system. yuzu has the same core code as Citra and much of the same OS High-Level Emulation (HLE). The core emulation and memory management of yuzu are based on Citra, albeit modified to work with 64-bit addresses. It also has a loader for the Switch games and Unicorn integration for CPU emulation. Yuzu uses Reverse Engineering process to figure out how games work, and how the Switch GPU works. Switch’s GPU is more advanced than 3DS’ used in Citra and poses multiple challenges to reverse engineer it. However, the RE process of yuzu is essentially the same as Citra. Most of their RE and other development is being done in a trial-and-error manner. OS emulation The Switch’s OS is based Nintendo 3DS’s OS. So the developers used a large part of Citra’s OS HLE code for yuzu OS. The loader and file system service was reused from Citra and modified to support Switch game dump files. The Kernel OS threading, scheduling, and synchronization fixes for yuzu were also ported from Citra’s OS implementation. The save data functionality, which allowed games to read and write files to the save data directory was also taken from 3DS. Switchbrew helped them create libnx, a userland library to write homebrew apps for the Nintendo Switch. (Homebrew is a popular term used for applications that are created and executed on a video game console by hackers, programmers, developers, and consumers.) The Switch IPC (Inter-process communication) process is much more robust and complicated than the 3DS’s. Their system has different command modes, a typical IPC request response, and a Domain to efficiently conduct multiple service calls. Yuzu uses the Nvidia services to configure the video driver to get the graphics output. However, Nintendo re-purposed the Android graphics stack and used it in the Switch for rendering. And so yuzu developers had to implement this even to get homebrew applications to display graphics. The Next Steps Being at a nascent stage, yuzu still has a long way to go. The developers still have to add HID (user input support) such as support for all 9 controllers, rumble, LEDs, layouts etc. Currently, the Audio HLE is in progress, but they still have to implement audio playback. Audio playback, if implemented properly, would be a major breakthrough as most complicated games often hang or go into a deadlock because of this issue. They are also working on resolving minor fixes to help them boot further in games like Super Mario Odyssey, 1-2-Switch, and The Binding of Issac. Be sure to read the entire progress report on the yuzu blog. Read Next AI for game developers: 7 ways AI can take your game to the next levelAI for Unity game developers: How to emulate real-world senses in your NPC agent behaviorUnity 2018.2: Unity release for this year 2nd time in a row!
Associated PressTRIPOLI, Libya (AP) – An airport official in the Libyan capital Tripoli says flights resumed out of the country’s airports after they were halted for over seven hours due to a strike by air traffic controllers.The official said the controllers went on strike Sunday to demand better pay and upgraded navigation and communications equipment. The official, who spoke on condition of anonymity because he is not authorized to speak to the media, called their demands legitimate. There was a backlog of passengers at airports in Tripoli, as well as in Benghazi, Misrata and other cities. Construction begins on Chandler hospital expansion project Check your body, save your life Flights resumed by Sunday evening. It was not clear if the controllers’ demands were met.(Copyright 2012 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.) Bottoms up! Enjoy a cold one for International Beer Day Mary Coyle ice cream to reopen in central Phoenix Comments Share Former Arizona Rep. Don Shooter shows health improvement Parents, stop beating yourself up Patients with chronic pain give advice Top Stories Sponsored Stories